| Bio |
Lymphocyte activation gene 3 (LAG-3, CD223) is a transmembrane protein with four extracellular IgG domains. The membrane-distal IgG domain contains a short amino acid sequence (extra loop) that is not found in other IgG superfamily proteins. The intracellular domain has a unique amino acid sequence (KIEELE) required for LAG-3 to exert a negative effect on T cell function. Learn more: LAG-3 immune checkpoint
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